Liphello tsa phuputso e ncha e hatisitsoeng koranteng ea Biomed Central BMC e bontšitse hore turmeric extract e sebetsa hantle joaloka paracetamol ho fokotsa bohloko le matšoao a mang a knee osteoarthritis (OA). Boithuto bo bontšitse hore motsoako oa bioavailable o sebetsa haholo ho fokotsa ho ruruha.
Osteoarthritis ke lefu le senyehang la manonyeletso a articular a khetholloang ke ho senyeha ha lefufuru, lesela le kopantsoeng, li-ligaments le lesapo le ka tlaase. Lipontšo tse tloaelehileng tsa osteoarthritis ke ho satalla le bohloko.
E etelletsoe ke Shuba Singhal, PhD, thuto ena ea kliniki e laoloang ka nako e sa lekanyetsoang e ile ea etsoa Lefapheng la Orthopedics ea Lok Nayak Jai Prakash Hospital / Maulana Azad Medical College, New Delhi. Bakeng sa thuto, bakuli ba 193 ba fumanoeng ba e-na le lefu la masapo a manonyeletso la lengole ba ne ba sa lebelloa ho fumana turmeric extract (BCM-95) e le 500 mg capsule ka makhetlo a mabeli ka letsatsi, kapa letlapa la 650 mg la paracetamol ka makhetlo a mararo ka letsatsi bakeng sa libeke tse tšeletseng.
Matšoao a ramatiki a mangole a bohloko, ho satalla ha manonyeletso, le ho fokotseha ha tšebetso ea 'mele li ile tsa hlahlojoa ho sebelisoa Western Ontario le McMaster Universities Osteoarthritis Index (WOMAC). Ka mor'a libeke tse tšeletseng tsa phekolo, tlhahlobo ea ba arabelang e bontšitse ntlafatso e kholo ho lintlha tsa WOMAC ho pholletsa le litekanyetso tsohle tse bapisoang le sehlopha sa paracetamol, le 18% ea sehlopha sa BCM-95 e tlaleha ntlafatso ea 50%, le 3% ea lithuto tse hlokometseng ntlafatso ea 70%.
Liphello tsena li ne li bonahala hantle ka lihlopha tsa sehlopha sa BCM-95 tsa ho ruruha ha serum: litekanyetso tsa CRP li fokotsoe ke 37.21%, 'me litekanyetso tsa TNF-α li ile tsa khaoloa ke 74.81%, e bontšang hore BCM-95 e sebetsa hantle ho feta paracetamol.
Boithuto bona e ne e le ho latela phuputso ea Arjuna e entsoeng nako e fetang selemo e fetileng e bonts'itseng khokahano e ntle lipakeng tsa sebopeho sa eona sa li-curcumin le tlhokomelo ea osteoarthritic.
"Sepheo sa thuto ea morao-rao e ne e le ho haha lithutong tsa pejana ho fana ka tlhaloso e ntlafetseng le e tobileng ka ho kenyelletsa matšoao a mangata le mokhoa o motle oa ho fana ka lintlha," ho boletse Benny Antony, mookameli ea kopanetsoeng oa Arjuna. "Phello e khahlanong le ramatiki ea BCM-95 ho osteoarthritis e bakoa ke bokhoni ba eona ba ho fetola matšoao a khahlanong le ho ruruha a TNF le CRP."
Knee OA ke sesosa se ka sehloohong sa bokooa le bohloko har'a batho ba baholo le maqheku. Ho hakanngoa hore 10 ho isa ho 15% ea batho bohle ba baholo ho feta lilemo tse 60 ba na le tekanyo e itseng ea OA, 'me tšoaetso e phahame ho basali ho feta banna.
"Phuputso ena e tiisa phello ea anti-arthritic ea BCM-95 'me e fana ka tšepo e nchafalitsoeng bakeng sa batho ba limilione ho ntlafatsa bophelo ba bona," ho boletse Nipen Lavingia, moeletsi oa tlhahiso ea lihlahisoa tsa Arjuna Natural ea lulang Dallas, TX.
"Re ntse re ithuta ho eketsehileng ka mekhoa ea curcumin's anti-inflammatory effect eo re lumelang hore ke phello ea bokhoni ba eona ba ho thibela matšoao a pro-inflammatory, a kang prostaglandins, leukotrienes, le cyclooxygenase-2. Ntle le moo, curcumin e bontšitsoe ho hatella li-cytokine tse 'maloa tsa pro-inflammatory le bakena-lipakeng ba tokollo ea tsona, joalo ka tumor necrosis factor-α (TNF-α), IL-1, IL-8, le nitric oxide synthase, "ho boletse Antony.
Motsoako o ikhethang oa BCM-95 oa li-curcuminoids le likaroloana tsa oli ea bohlokoa tse nang le turmerone e hlola litšitiso tse ikhethang tsa curcumin ka lebaka la tlhaho ea eona e phahameng ea lipophilic.
Nako ea poso: Apr-12-2021